![]() ![]() Here, we describe the course of antibody-mediated and cellular SARS-CoV-2-directed immunity over a time period of 1 year in a cohort of hospital employees, who were infected with SARS-CoV-2 during the first COVID-19 wave in spring 2020 and recovered subsequently. Similar to other countries, health care workers in Germany are overrepresented among COVID-19-infected individuals. Only few studies addressed time periods longer than 6–8 months and especially parameters of cellular immunity have been insufficiently studied to date. However, surrogate parameters for and the duration of protection from reinfection have not been defined so far. Reinfections have rarely been reported, and generally follow mild courses. ![]() It has become clear that the strength of the immune response underlies considerable interindividual variability, and decreases with age and over time. However, investigations into the time course of SARS-CoV-2-directed immunity after infection have yielded conflicting results so far. Comparable to other infectious viral diseases, at least temporary immunity is assumed for most individuals after recovery from a SARS-CoV-2 infection.
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